Publications
italicized name= QCC lab trainee
Peer-reviewed articles
30. Johnson B*, Shuai Y*, Schweinsberg J, Curtius K. (2023) cloneRate: fast estimation of single-cell clonal dynamics using coalescent theory. Bioinformatics btad561. *joint first authors
29. Lu B, Curtius K, Graham TA, Yang Z, Barnes CP (2023) CNETML: Maximum likelihood inference of phylogeny from copy number profiles of spatio-temporal samples. Genome Biol (in press)
28. Talwar J, Laub D, Pagadala M, Castro A, Lewis M,..., Curtius K, Zanetti M, Carter H. (2023) Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility. Am J Hum Genet (in press)
27. Guccione C, McDonald D, Fielding-Miller R, Curtius K, Knight R. (2023) You are what you excrete. Nat Microbiol 8:1002–1003.
26. Patel R*, Curtius K*, Mann R, Fletcher J, Cuthill V, et al. (2023) Long-term outcomes of pouch surveillance and risk of neoplasia in familial adenomatous polyposis. Endoscopy (in press). *joint first authors
25. Ma SD, Guccione C, Linnemeyer K, Weissbrod PA, Curtius K, et al. (2023) Oral Microbiome Diversity Between Patients with Normal vs Elevated Salivary Pepsin Levels and its Implication in Gastroesophageal Reflux Disease. Foregut 3(1):131-134.
24. Ghosh P, Laub D, Campos VJ, Vo DT, Guccione C,.. Curtius K, Sahoo D. (2022) AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas. JCI Insight 7(18):e161334.
23. Guo Q, Lakatos E, Al Bakir I, Curtius K, Graham TA, Mustonen V. (2022) The mutational signatures of formalin fixation on the human genome. Nat Commun 13:4487.
22. Curtius K, Gupta S, Boland CR. (2022) Lynch Syndrome - a mechanistic and clinical practice update. Aliment Pharmacol Ther, 1–18. doi: 10.1111/apt.16826
21. Sepich-Poore, GD, Guccione C, Laplane L, Pradeu T, Curtius K, Knight R. (2022) Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process BioEssays, e2100252.
20. Curtius K*, Kabir M*, Al Bakir I, Choi CHR, Hartono J, et al. (2022) Multi-centre derivation and validation of a colitis-associated colorectal cancer risk prediction web-tool. Gut 71(4):705-715. *joint first authors
19. Guccione C, Yadlapati R, Shah S, Knight R, Curtius K. (2021) Challenges in determining the role of microbiome evolution in Barrett’s esophagus and progression to esophageal adenocarcinoma. Microorganisms 9(1):2003
18. Curtius K, Rubenstein JH, Chak A, Inadomi JM. (2021) Computational modelling suggests that Barrett's oesophagus may be the precursor of all oesophageal adenocarcinomas. Gut 70(8):1435-1440
17. Luebeck GE, Vaughan TL, Curtius K, Hazelton WD. (2021) Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma. PLoS Comput Biol 17(5):e1008961
16. Curtius K, Dewanji A, Hazelton WD, Rubenstein JH, Luebeck EG. (2021) Optimal timing for cancer screening and adaptive surveillance using mathematical modeling. Cancer Res 81(4):1123-1134
15. Tamura N, Shaikh N, Muliaditan D, McGuinness J, Moralli D, et al. (2020) Mechanisms of Chromosomal Instability in High-grade Serous Ovarian Carcinoma. Cancer Res 80(20):4946-59
14. Saunderson EA, Baker AM, Williams M, Curtius K, Jones JL, et al. (2020) A novel method of single strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples. NAR Genom and Bioinform 2(1):lqz017
13. Rockne R, Hawkins-Daarud A, Swanson K, Sluka J, Glazier J, et al. (2019) The 2019 Mathematical Oncology Roadmap. Phys Biol doi: 10.1088/1478-3975/ab1a09
12. Baker AM*, Cross WC*, Curtius K*, Al Bakir I*, Choi CHR*, et al. (2019) The evolutionary history of human colitis-associated colorectal cancer. Gut 68:985-995., *joint first authors
11. Luebeck EG, Hazelton WD, Curtius K, Maden S, Yu M, et al. (2019) Implications of Epigenetic Drift in Colorectal Neoplasia. Cancer Res 79(3):495-504
10. Al Bakir I, Curtius K, Graham TA. (2018) From Colitis to Cancer: an Evolutionary Trajectory That Merges Maths and Biology. Front Immunol 9:2368
9. Curtius K, Wright NA, Graham TA. (2018) An evolutionary perspective on field cancerization. Nat Rev Cancer 18: 19-32.
8. Luebeck EG, Curtius K, Hazelton WD, Maden SK, Yu M, et al. (2017) Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma. J Clin Epigenet 9(113): 1-10.
7. Kroep S*, Heberle C*, Curtius K*, Lansdorp-Vogelaar I, Hazelton WD, et al. (2017) Radiofrequency Ablation of Barrett’s Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis. Clin Gastroenterol Hepatol 15(9):1471-1474, *joint first authors
6. Curtius K, Wong C-J, Hazelton WD, Kaz AM, Chak A, Willis JE, et al. (2016) A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus. PLoS Comput Biol 12(5): e1004919.
5. Hazelton WD, Curtius K, Inadomi JM, Vaughn TL, Meza R, et al. (2015) The role of gastroesophageal reflux and other factors during progression to esophageal adenocarcinoma. Cancer Epidemiol Biomarkers Prev: cebp–0323
4. Curtius K, Hazelton WD, Jeon J, Luebeck EG (2015) A Multiscale Model Evaluates Screening for Neoplasia in Barrett’s Esophagus. PLoS Comput Biol 11(5):e1004272.
3. Kong CY, Kroep S, Curtius K, Hazelton WD, Jeon J, et al. (2014) Exploring the Recent Trend in Esophageal Adenocarcinoma Incidence and Mortality Using Comparative Simulation Modeling. Cancer Epidemiol Biomarkers Prev 23(6):997-1006
2. Luebeck EG, Curtius K, Jeon J, Hazelton WD (2013) Impact of Tumor Progression on Cancer Incidence Curves. Cancer Res Feb 1;73(3):1086-96
Book chapters
1. Curtius K, Wright NA, Graham TA. (2017) Evolution of Premalignant Disease. Cold Spring Harb Perspect Med. doi: 10.1101/cshperspect.a026542